为研究核黄素的新功能,进行了核黄素阻抑动物致畸作用的实验。大鼠分为三个剂量组,各组动物分别以每日每头一次剂量50μg,250μg,和1000μg的核黄素灌胃一周,妊娠后各组包括对照组一律按0.75mg/kg体重的农药“敌枯双”每天灌胃染毒一次,并继续按上述方法给予核黄素。研究结果表明,核黄素对“敌枯双”染毒后孕鼠的影响,在250μg和1000μg组其吸收胎率和活胎率与对照组相比有非常显著的差异(P<0.01);50μg和1000μg组的着床率与脑畸形率也明显低于对照组。各剂量组的外观畸形率和内脏畸形率虽低于对照组,但经统计分析没有显著差异。核黄素对染毒后孕鼠的其他各项观察指标与对照组相比,差别也无统计学意义。 In order to study the new function of riboflavin, experiments were conducted to evaluate the teratogenic effects of riboflavin in animals. Rats were divided into three dose groups, each group was given a daily dose of 50μg, 250μg, and 1000μg of riboflavin gavage for one week after pregnancy, each group including the control group all 0.75mg / kg body weight of pesticides “Enemy dry double” once daily intragastric administration, and continue to give riboflavin as above. The results showed that the effects of riboflavin on the pregnant mice after exposure to “Zuqian Shuang” were significantly different from those in the control group (P <0.01) in the 250μg and 1000μg groups. The implantation rate and the rate of deformity in the 50μg and 1000μg groups were also significantly lower than those in the control group. Although the appearance deformity rate and visceral malformation rate of each dose group were lower than that of the control group, there was no significant difference by statistical analysis. Riboflavin on pregnant rats after exposure to the other various indicators compared with the control group, the difference was not statistically significant.