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目的:探讨甘草酸二铵联合益气养阴、清热凉血中药治疗自身免疫性肝炎的临床疗效。方法:采用前瞻性研究方法,共纳入病例37例,其中男9例,女28例,均给与甘草酸二铵制剂治疗,同时配合益气养阴、清热凉血中药口服,疗程3个月,观察治疗前后患者肝脏功能、症状总积分的变化及预后转归。结果:与治疗前相比,患者肝脏功能明显改善,表现为ALT、AST、TB IL显著下降,治疗前后比较有显著差异(P<0.01)。观察终点时,17/37(45.9%)的患者达临床痊愈,17/37(45.9%)的患者达临床好转,3/37(8.1%)的患者未愈。结论:甘草酸二铵联合益气养阴、清热凉血中药治疗自身免疫性肝炎具有较好的近期疗效,值得进一步深入研究。
Objective: To investigate the clinical efficacy of diammonium glycyrrhizinate combined with nourishing yin and clearing away heat and cooling blood herbs in the treatment of autoimmune hepatitis. Methods: A total of 37 cases including 9 males and 28 females were enrolled in the prospective study. All patients were given diammonium glycyrrhizinate preparations. At the same time, they were given Chinese herbs qi and nourishing yin and clearing heat and cooling blood for 3 months , Observed before and after treatment of patients with liver function, the total score of symptoms and prognosis. Results: Compared with those before treatment, the liver function of patients was significantly improved. The levels of ALT, AST and TB IL were significantly decreased. There was significant difference before and after treatment (P <0.01). At the end of the study, 17 of 37 (45.9%) patients achieved clinical recovery, 17 of 37 (45.9%) achieved clinical improvement, and 3 of 37 (8.1%) did not. Conclusion: Diammonium glycyrrhizinate combined with qi and nourishing yin and Qingre Liangxue Chinese medicine in the treatment of autoimmune hepatitis have good short-term curative effect, which deserves further study.