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目的分析韶关市近6年来新生儿先天性甲状腺功能低下症(CH)的筛查情况和发病率。方法新生儿出生72h充分哺乳6次后足跟采血,滴在特殊的滤纸(美国S﹠S903滤纸)片上,用时间分辨荧光免疫分析法测定促甲状腺素浓度。TSH≥10.0U/L,通知原采血单位立即召回再采血复查,结果仍超过10.0U/L,由本院直接召回抽血确诊。结果6年共筛查新生儿77220例,可疑阳性患儿572例,确诊33例,发病率为1/2340。结论韶关市新生儿CH发病率高于全国统计率,可能与环境因素及饮食习惯有关。
Objective To analyze the screening status and incidence of neonatal congenital hypothyroidism (CH) in Shaoguan City in recent 6 years. Methods The newborn was breastfeed six times after breastfeeding six times and then dripped on a special filter paper (American S & S 903 filter paper). The concentration of thyrotropin was determined by time-resolved fluorescence immunoassay. TSH≥10.0U / L, notify the original unit of blood immediately recall and then recheck the blood, the result is still more than 10.0U / L, the hospital direct recall of blood confirmed. Results A total of 77,220 newborns were screened in 6 years, 572 were positive in suspicious cases and 33 were diagnosed with a prevalence of 1 in 2340. Conclusion The incidence of neonatal CH in Shaoguan City is higher than the national statistical rate, which may be related to environmental factors and dietary habits.