第三代头孢菌素抗菌谱广,均可胃肠外给药。本文讨论其中6个:头孢噻肟(cefotaxime)、头孢唑肟(ceftizoxime)、头孢曲松(ceftriaxone)、拉他头孢(moxalactam)、头孢哌酮(cefoperazone)和头孢他啶(ceftazidime)。不良反应总发生率低于氨基糖甙类;以头孢噻肟和头孢唑肟最低。共同的不良反应为注射部位疼痛、静脉炎、发热、瘙痒、皮疹、厌食、恶心、呕吐、非特异性腹泻、肝功能异常、血清Coomb抗球蛋白试验直接阳性等,一般不严重,停药后就迅速消失。出血可能是最严重的不良反应。凝血缺陷和出血第三代头孢菌素的最严重不良反应是凝血病和出血。发生原理,主要是维生素K反 The third generation cephalosporin antibacterial spectrum wide, can be parenteral administration. Six of these are discussed herein: cefotaxime, ceftizoxime, ceftriaxone, moxalactam, cefoperazone and ceftazidime. The total incidence of adverse reactions than aminoglycosides; to cefotaxime and ceftizoxime lowest. The common adverse reactions were pain at injection site, phlebitis, fever, itching, rashes, anorexia, nausea, vomiting, non-specific diarrhea, abnormal liver function, direct positive serum Coomb antiglobulin test, etc., generally not serious Quickly disappear. Bleeding may be the most serious adverse reaction. Blood coagulation defects and bleeding The third-generation cephalosporins the most serious adverse reactions are coagulopathy and bleeding. Occurrence principle, mainly vitamin K anti