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未完成3次白喉类毒素注射的白喉病人的家庭成员或其他密切接触者,需立即注射一次含白喉类毒素的制剂,并按规定完成免疫程序。如未完成3次,在5年内未注射过含白喉类毒素制剂者,应根据其年龄加强注射1次。所有密切接触者应观察7天。未免疫或免疫不全的无症状密切接触者,应立即进行药物预防,用苄星青霉素(小于6岁者,60万单位;大于等于6岁者120万单位,肌注,或口服红霉素(儿童:40mg/kg/日;成人:1g/日)7~10天。抗生素预防前后的细菌学培养,可能有助于随访和管理接触者,其未免疫的家庭接触
Family members or other close contacts of diphtheria patients who have not completed 3 diphtheria toxoid injections are required to receive an immediate diphtheria toxoid-containing preparation and complete the immunization schedule as prescribed. If not completed 3 times within 5 years without diphtheria toxoid-containing formulations, should be based on their age to strengthen the injection once. All close contacts should be observed for 7 days. Non-immunocompromised asymptomatic close contacts should be promptly drug-controlled with benzathine penicillin (less than 6 years of age, 600,000 units; 120 million units of patients over the age of 6, intramuscularly, or oral administration of erythromycin Children: 40 mg / kg / day; Adult: 1 g / day) 7 to 10 days Bacteriological culture before and after antibiotic prophylaxis may help to follow up and manage contact with uninjured family contacts