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目的:探讨中枢神经系统窦组织细胞增生症的诊断及治疗。方法:对我院收治的2例颅内窦组织细胞增生症病例的临床资料进行回顾性分析。结果:2例患者病灶分别位于左侧大脑镰旁和左侧中颅窝。术前CT,MRI诊断为脑膜瘤。手术全切肿块。术后病理和免疫组化发现病变组织由大量淋巴细胞、浆细胞及S100和CD68标记阳性的组织细胞构成,并呈“明暗”相间的组织学特征,部分组织细胞内有吞噬淋巴细胞现象。结论:原发颅内窦组织细胞增生症少见,易被误诊,免疫组化检查有助于鉴别诊断。手术是治疗本病的主要手段。
Objective: To investigate the diagnosis and treatment of sinusoidal cell proliferation in central nervous system. Methods: The clinical data of 2 cases of intracranial sinusoidal histiocytosis in our hospital were analyzed retrospectively. Results: Two cases of lesions were located in the left side of the falx and the left middle cranial fossa. Preoperative CT, MRI diagnosis of meningioma. Surgery full cut lumps. Postoperative pathology and immunohistochemistry showed that the lesion was composed of a large number of lymphocytes, plasma cells and S100 and CD68 positive tissue cells, with histological features of “light and shade” phase. Some tissues had phagocytic lymphocytes. Conclusion: The primary intracranial sinusoid cell hyperplasia is rare and easily misdiagnosed. Immunohistochemical examination is helpful for the differential diagnosis. Surgery is the main means of treatment of this disease.