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目的:探讨神经节苷脂治疗新生儿缺血缺氧性脑病的临床疗效。方法:将40例新生儿缺氧缺血性脑病者根据入院顺序均分为治疗组与对照组各20例,两组均给予胞二磷胆碱等支持治疗,治疗组加用单唾液酸四己糖神经节苷脂治疗。结果:治疗组20例,显效14例,有效5例,无效1例,总有效率为95.0%;对照组20例,显效4例,有效10例,无效6例,总有效率70.0%,治疗组疗效优于对照组(P<0.05),差异有统计学意义;两组均无明显不良反应,不良反应情况对比无明显差异(P>0.05)。结论:新生儿缺血缺氧性脑病发病危急,单唾液酸四己糖神经节苷脂辅助治疗能提高疗效,值得临床推广应用。
Objective: To investigate the clinical effect of ganglioside on neonatal hypoxic-ischemic encephalopathy. Methods: Forty neonates with hypoxic-ischemic encephalopathy were divided into treatment group and control group according to the order of admission. Twenty patients in each group were given citicoline and other supportive therapy. Hexose ganglioside treatment. Results: The treatment group of 20 cases, 14 cases markedly effective in 5 cases, 1 case of ineffective, the total effective rate was 95.0%; control group of 20 cases, 4 cases markedly effective in 10 cases, 6 cases ineffective, the total effective rate was 70.0% The curative effect was better than that of the control group (P <0.05), the difference was statistically significant. There was no obvious adverse reaction between the two groups, and there was no significant difference between the two groups (P> 0.05). Conclusion: Neonatal hypoxic-ischemic encephalopathy is in critical condition. Adjuvant monosialotetrahexose ganglioside can improve the curative effect and is worthy of clinical application.