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临床上一般不用阿托品治疗毛地黄类药物中毒性心律失常。而本实验表明阿托品具有显著的预防效果,且其效果优于阿托品加心得安及等剂量的心得安。家兔38只,用乌拉坦麻醉,分四组,分别自静脉注射毒毛旋花子甙-K 加①生理盐水;②阿托品;③阿托品加心得安;④心得安。各药剂量均为0.3毫克/公斤。一小时后作第二次实验,①和②组,⑧和④组交叉用药,各药剂量减为0.2毫克/公斤。根据心电图表现是否有明显心律失常,判断为无效(一)、部份有效(±)、及有效(+)三级。记下各组各级例数,用 Ridit 分析法与盐水组比较。结果表明:阿托品的效果最优(■=0.775,P<0.01);其次为阿托品加心得安(■=0.632,p≤0.05);而心得安组((?)=0.603)与盐水组之差异尚未达到显著意义(95%可信下限=0.467<0.500)。此外,注射前后心率比较:除心得安组有效例平均心率显著减慢外,其余二组有效例及盐水组心律失常例心率改变均无显著性意义。阿托品的作用,可能是由于阻断迷走后,加快了窦性心律和房室传导,从而胜过异搏心律以恢复窦性心律。但在有效剂量内,阿托品并不使心率快过正常心率。阿托品加心得安组效果不如单用阿托品,可能是心得安在阻断交感以压抑异搏心律的同时,也减慢了窦性心律及房室传导,从而削弱了阿托品的效果所致。
Atropine generally do not have clinical treatment of Foxtip toxic arrhythmia. And this experiment shows that atropine has a significant preventive effect, and its effect is superior to atropine plus propofol and other doses of propofol. Rabbits 38, with urethane anesthesia, divided into four groups, respectively, intravenous injection of venom spinosad-K plus ① normal saline; ② atropine; ③ atropine plus propofol; ④ peace of mind. Each dose of medicine is 0.3 mg / kg. One hour later for the second experiment, ① and ② group, ⑧ and ④ group cross medication, the dose of each drug reduced to 0.2 mg / kg. According to the ECG showed significant arrhythmia, judged as invalid (a), part of the effective (±), and effective (+) three. Write down the number of cases at each level, using Ridit analysis and saline group comparison. The results showed that the effect of atropine was the best (■ = 0.775, P <0.01), followed by etoposide (■ = 0.632, p≤0.05) Not yet reached significance (95% confidence limit = 0.467 <0.500). In addition, before and after the injection of heart rate comparison: In addition to the effective group of patients with effective heart rate significantly slower average heart rate, the other two groups of effective cases and arrhythmia heart rate cases no significant change. The role of atropine, may be due to block the vagus, accelerated sinus rhythm and atrioventricular conduction, which beat the beating heart rate to restore sinus rhythm. But in the effective dose, atropine does not make heart rate faster than normal heart rate. Atropine plus security group effect than atropine alone, may be the experience of Ann sympathy to suppress the heart rate at the same time, but also slowed the sinus rhythm and atrioventricular conduction, thus weakening the effect of atropine.