在过去十年中,临床越来越重视室性心律失常的治疗。这主要是由于某些类型室性异位搏动是构成缺血性心脏病病人猝死的一个危险因素。其次,日益增多的心脏停搏复苏病人,除非接受治疗,否则有复发的危险。此外,动态心电图监护和运动负荷试验的广泛应用,在许多心肌功能显著障碍病人中发现了潜在的严重室性心律失常。这些危险病人的识别使内科医师面临投用适当抗心律失常药物的问题,然而诸如奎尼丁、普鲁卡因酰胺和双异丙吡胺等传统药物常无效或有毒性。发展抗心律失常手段的迫切需要刺激了 In the past decade, more and more clinical attention to the treatment of ventricular arrhythmias. This is mainly because some types of ventricular ectopic beats are a risk factor for sudden death in patients with ischemic heart disease. Second, a growing number of cardiac arrest patients are at risk for relapse unless they receive treatment. In addition, the widespread use of Holter monitoring and exercise stress testing has identified potentially serious ventricular arrhythmias in many patients with significant myocardial dysfunction. The identification of these at-risk patients exposes physicians to the problem of administering appropriate anti-arrhythmic drugs, whereas traditional drugs such as quinidine, procainamide and bispyribacil are often ineffective or toxic. The urgent need to develop anti-arrhythmic means is stimulated