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目的 了解温州地区静脉吸毒者经血传播疾病的感染情况。方法 采集静脉吸毒者血液标本 ,分离血清 ,用半巢式PCR检测TTV ,用ELISA检测抗 -HCV、HBsAg、抗 -HBs、HBeAg、抗 -HBe、抗 -HBc等。 结果 共检测 30 6例 ,TTV、抗 -HCV、HBsAg、抗 -HBs、HBeAg、抗 -HBe、抗 -HBc的阳性率分别为 7 5 2 %、4 2 4 8%、19 6 1%、4 4 12 %、7 19%、7 84 %和 4 1 5 0 %。乙肝五项标志物中一项或以上阳性者 2 2 6例 ,感染率为73 86 %。HCV、TTV和HBV同时检出率高。吸毒者不同血型的TTV、HCV、HBV感染率无显著差异。结论 静脉吸毒者是经血传播疾病的高危人群 ,几种疾病可同时或重叠感染 ;共有未经灭菌的注射器可造成交叉感染 ,可能是吸毒者感染这些疾病的主要原因。故应采取控制措施 ,降低吸毒人群感染这些疾病的频率。
Objective To understand the prevalence of blood-borne infections among intravenous drug users in Wenzhou area. Methods Blood samples of intravenous drug addicts were collected, serum was separated, TTV was detected by semi-nested PCR, anti-HCV, HBsAg, anti-HBs, HBeAg, anti-HBe and anti-HBc were detected by ELISA. Results A total of 30 6 cases were detected. The positive rates of TTV, anti-HCV, HBsAg, anti-HBs, HBeAg, anti-HBe and anti-HBc were 75.2%, 42.48%, 19.61%, 4 4 12%, 7 19%, 7 84% and 4150%. Two or six of the five markers of hepatitis B were positive, with an infection rate of 73.86%. HCV, TTV and HBV at the same time high detection rate. There was no significant difference in the prevalence of TTV, HCV and HBV among different drug users. Conclusions Intravenous drug users are at high risk of blood-borne diseases. Several diseases can be infected simultaneously or overlappingly. A total number of non-sterile syringes can cause cross-infection, which may be the main reason for these infections among drug users. Therefore, control measures should be taken to reduce the frequency of drug abuse among these people.