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目的:观察伊班膦酸钠注射液并化疗对恶性肿瘤骨转移疼痛、体能及生活质量的影响。方法:对58例有骨转移的恶性肿瘤患者,按治疗意愿分为2组,治疗组(28例)和对照组(30例)。治疗组在化疗间歇期使用伊班膦酸钠注射液,对照组为单纯化疗。化疗2疗程后观察生活质量的变化,骨痛评分的变化,血清碱性磷酸酶(ALP)及钙离子(Ca2+)水平的变化,毒副作用。结果:治疗组总体生活质量评分为345±152,对照组为242±134,差异有显著性意义(t=2.74,P<0.05)。治疗组治疗后骨痛评分为6.4±2.2,对照组为12.3±1.7,差异有显著性意义(t=9.02,P<0.05)。血清ALP和Ca2+治疗后治疗组为(90±15)U/L,(1.00±0.05)mmol/L,对照组为(160±20)U/L,(1.06±0.04)mmol/L,差异有显著性意义(t=14.99,5.06)。肿瘤疗效的变化无统计学意义(χ2=0.254,P>0.05),且无明显毒副作用。结论:伊班膦酸钠注射液是第3代双膦酸盐类药物,其治疗和预防恶性肿瘤骨转移有安全、有效、耐受性良好的特点,可有效的缓解癌症患者疼痛,增强体能,改善其生活质量。
Objective: To observe the effects of ibandronate sodium injection and chemotherapy on bone metastasis pain, physical fitness and quality of life in patients with malignant tumors. Methods: Fifty-eight patients with malignant tumor with bone metastases were divided into two groups according to the treatment intention: treatment group (n = 28) and control group (n = 30). The treatment group used ibandronate sodium injection during the intermittent chemotherapy and the control group was chemotherapy alone. Changes of quality of life, changes of bone pain scores, changes of serum alkaline phosphatase (ALP) and calcium (Ca2 +) levels and side effects were observed after 2 cycles of chemotherapy. Results: The overall quality of life score was 345 ± 152 in the treatment group and 242 ± 134 in the control group, with significant difference (t = 2.74, P <0.05). The pain score of the treatment group after treatment was 6.4 ± 2.2 and that of the control group was 12.3 ± 1.7, the difference was significant (t = 9.02, P <0.05). The serum levels of ALP and Ca2 + in the treatment group were (90 ± 15) U / L, (1.00 ± 0.05) mmol / L, and those in the control group were (160 ± 20) U / L and Significance (t = 14.99,5.06). There was no significant difference in the curative effect of tumor (χ2 = 0.254, P> 0.05), and no obvious side effects. Conclusion: Ibandronate sodium injection is the third generation of bisphosphonates, which is safe, effective and well tolerated in the treatment and prevention of bone metastases of malignant tumors. It can effectively relieve pain and increase physical ability of cancer patients , Improve their quality of life.