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目的:讨论儿童及青少年分化型甲状腺癌(differentiated thyroid carcinoma,DTC)患者手术后首次放射性碘(radioiodine,RAI)治疗清除残余甲状腺组织的疗效的影响因素。方法:回顾性分析首次接受大剂量清除残余甲状腺组织治疗的患者88例,分为清甲治疗成功组与未成功组,对数据进行秩和检验、卡方检验或Fisher确切率法筛选影响因素,并做logistics回归分析。结果:用单因素分析筛选出治疗前甲状腺摄碘率(radioactive iodine uptake,RAIU)、淋巴结转移、肺转移是影响首次清甲治疗疗效的因素。多因素分析提示RAIU及淋巴结转移为影响首次清甲治疗疗效的独立影响因素。结论:儿童及青少年分化型甲状腺癌患者首次清甲治疗疗效的影响因素有RAIU、淋巴结转移、肺转移,其中RAIU、淋巴结转移的影响更为明显。
Objective: To discuss the influencing factors of the efficacy of the first radioiodine (RAI) in the treatment of residual thyroid tissue in children and adolescent differentiated thyroid carcinoma (DTC). Methods: A retrospective analysis of 88 patients who were treated for the first time with large doses of remnant thyroid tissue was divided into successful and unsuccessful treatment groups. The data were subjected to rank sum test, chi-square test or Fisher exact test, And do logistics regression analysis. Results: Radioactive iodine uptake (RAIU), lymph node metastasis and lung metastasis before screening were the factors influencing the curative effect of the first mechlorea. Multivariate analysis suggested that RAIU and lymph node metastasis were the independent influencing factors for the treatment of the first mecca treatment. Conclusion: The influencing factors of RAIU, lymph node metastasis and lung metastasis in children and adolescent patients with differentiated thyroid carcinoma for the first time include RAIU and lymph node metastasis.