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白细胞介素-33与其受体ST2L结合可促进Th2方向的免疫炎症反应,白细胞介素-33/ST2L通路调节免疫反应与多种疾病的发生与进展有关,研究白细胞介素-33/ST2L通路与心血管系统疾病、哮喘等变态反应性疾病、自身免疫性疾病、皮肤系统性疾病及纤维化相关疾病等的关系可为疾病的治疗提供新思路和新方法。本文就白细胞介素-33/ST2L通路与疾病相关性的研究进展作一综述。
Interleukin-33 and its receptor ST2L can promote immune inflammation in the Th2 direction, IL-33 / ST2L pathway regulation of immune response and the occurrence and progression of a variety of diseases, interleukin-33 / ST2L pathway and Cardiovascular diseases, asthma and other allergic diseases, autoimmune diseases, skin diseases and fibrosis-related diseases can provide new ideas and new methods for the treatment of diseases. This article reviews the research progress of the relationship between interleukin-33 / ST2L pathway and diseases.