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①目的探讨癌周肝组织与肝癌组织发生之间的关系。②方法应用免疫组织化学方法对６０例原发性肝癌及其癌周组织中Ｃ－ｍｙｃ基因进行检测。③结果Ｃ－ｍｙｃ基因在肝癌和癌周增生结节及癌周肝硬变组织中的阳性率分别为３８．３％（２３／６０），４０．５％（１５／３７）和２６．７％（８／３０）。经统计学处理，肝癌与增生结节、肝硬变组织间差异均无显著性（χ２＝０．０５，１．２１，Ｐ均＞０．０５），增生结节与肝硬变组织间差异亦无显著性（χ２＝１．４１，Ｐ＞０．０５）。④结论Ｃ－ｍｙｃ癌基因过度表达是肝癌癌变过程中的重要因素；Ｃ－ｍｙｃ癌基因的过度表达可能与癌周增生结节的恶性转化有较密切的关系。癌周增生结节属癌前期病变，与肝癌的发生有关
Objective To explore the relationship between the hepatic tissue and the occurrence of hepatocellular carcinoma. 2 Methods Immunohistochemistry was used to detect the C-myc gene in 60 cases of primary liver cancer and its surrounding tissues. 3 Results The positive rates of C-myc gene in hepatocellular carcinoma and pericancerous nodules and cirrhosis were 38.3% (23/60), 40.5% (15/37) and 26.7 respectively. %(8/30). After statistical analysis, there was no significant difference between hepatocellular carcinoma and hyperplastic nodules and cirrhosis tissues (χ2=0.05, 1.21, P>0.05), and the difference between hyperplastic nodules and cirrhosis tissues. There was no significant difference (χ2=1.41, P>0.05). 4 Conclusion Overexpression of C-myc oncogene is an important factor in the process of hepatocarcinogenesis; overexpression of C-myc oncogene may be closely related to the malignant transformation of pericancerous nodules. Pericytic nodules are precancerous lesions and are associated with the occurrence of liver cancer