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造血干细胞异常和免疫功能异常在再生障碍性贫血的发病机制中起重要作用,再生障碍性贫血存在遗传学及谷胱甘肽转移酶异常。采用免疫抑制及造血干细胞移植治疗取得了明显疗效,目前一些新的免疫抑制剂治疗方法正在尝试应用。
Abnormalities in hematopoietic stem cells and immune dysfunction play an important role in the pathogenesis of aplastic anemia. Genetics and glutathione transferase abnormalities exist in aplastic anemia. The use of immunosuppression and hematopoietic stem cell transplantation has achieved significant therapeutic effect, some new immunosuppressive therapy is trying to apply.