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为评价急性心肌梗塞(AMI)再灌注治疗前、后采用心电图计分法估测的不同时间的梗塞面积,以寻找早期精确评价再灌注治疗效果的时间段,对7条犬结扎左冠状动脉前降支,制成 AMI 模型,结扎前、结扎后4 h 及开放结扎血管后0.5、1、2、3、4、5和6 h 分别做标准12导联心电图处死实验犬,取出心脏测梗塞心肌面积并与心电图计分法(采用 Clemmensen 等的公式)估测的面积进行对比。结果表明,血管再通后1 h 及以后采用心电图计分法估测的面积与实测面积相近且均小于结扎后面积(P<0.05),二者间有显著的相关性(P<0.01)。结论:血管再通后1 h 用心电图计分法估测的面积可较好地定量评价再灌注治疗效果。
To evaluate the infarct size estimated by electrocardiogram score before and after AMI reperfusion in order to find out the exact time of reperfusion therapy in early stage of acute myocardial infarction (AMI) reperfusion, the left anterior coronary artery The experimental animals were sacrificed by standard 12-lead electrocardiogram (ECG) at 4 h after ligation and 0.5, 1, 2, 3, 4, 5 and 6 h after ligation. Area and compared with the area estimated by electrocardiographic score (using the formula of Clemmensen et al.). The results showed that the area estimated by electrocardiogram scoring method at 1 h after revascularization was similar to the measured area and less than the area after ligation (P <0.05), with significant correlation (P <0.01). Conclusion: The area estimated by electrocardiogram scoring 1 h after recanalization can be used to evaluate the effect of reperfusion.