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(二) 药酶抑制作用:某些药物对肝药酶活性有抑制作用,能使另外一些通过药酶代谢的药物代谢速度减慢,血药浓度升高,半衰期延长,从而使药效增强,容易引起中毒。如氯霉素属于较强的药酶抑制药,当与苯妥英钠合用时,则使苯妥英钠代谢缓慢,血药浓度升高,引起眩晕、运动失调、眼球震颤等毒性反应。异菸肼也有较强的抑制肝药酶的作用。用异菸肼治疗伴有癫痫的结核病人,当加服苯妥英钠后,约有10％的患者血药浓度升高,其中某些人出现中毒症
(B) drug enzyme inhibition: Some drugs inhibit hepatic enzyme activity, can make other drug metabolism through the drug metabolism slow down the drug, blood drug concentration, half-life prolongation, so that the efficacy increased, Easily cause poisoning. Such as chloramphenicol is a strong drug enzyme inhibitors, when combined with phenytoin, the phenytoin sodium metabolism is slow, blood concentration, causing dizziness, dyskinesia, nystagmus and other toxic reactions. Isoniazid also has a strong inhibitory effect of liver enzyme. Treatment with isoniazid in TB patients with epilepsy increases plasma concentrations in about 10% of patients when phenytoin is added, and some of them develop toxicosis