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文献报道新喹诺酮类的环丙沙星、依诺沙星及培氟沙星能抑制肝脏微粒体系中细胞色素P—450的同功酶,该酶与甲基黄嘌呤的代谢有关,可降低人体内,特别是老年人体内茶碱清除率,而使血中茶碱浓度增高。氧氟沙星和诺氟沙星抑制P-450的同功酶作用甚小。当氧氟沙星与氨茶碱同时应用时,血中茶碱浓度并不显著增高。为证实以上观点,本文选择老年慢性肺心病缓解期病人5例(年龄62～73岁),肝肾功能均在正常范围。健
The new quinolones ciprofloxacin, enoxacin and pefloxacin have been reported in the literature to inhibit cytochrome P-450 isoenzyme in the liver particulate system, which is related to the metabolism of methylxanthine, In vivo, especially in the elderly, theophylline clearance, leaving the blood concentration of theophylline increased. Ofloxacin and norfloxacin inhibition of P-450 isozymes little effect. When ofloxacin and aminophylline applied at the same time, the blood concentration of theophylline is not significantly increased. In order to confirm the above viewpoints, we selected 5 patients (aged 62-73 years) with remission of elderly patients with chronic cor pulmonale, liver and kidney function were in the normal range. Kin