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目的:观察肺积1号方对肺癌小鼠淋巴细胞亚群的影响,探讨肺积1号方抗肿瘤机理。方法:建立肺癌小鼠模型,将小鼠随机分为健康对照组、荷瘤对照组、中药组、环磷酰胺组,给药14 d后,测定瘤指数、肿瘤抑制率、胸腺指数、脾指数以及T细胞亚群变化,分离脾淋巴细胞观察其对Lewis肺癌细胞生长抑制作用。结果:中药组和环磷酰胺组均明显抑制肿瘤生长,中药组T细胞亚群得以纠正,与健康对照组比较,差异无统计学意义(P>0.05);环磷酰胺组与荷瘤对照组均存在免疫失衡;中药组脾脏淋巴细胞抗肿瘤细胞能力较荷瘤对照组、环磷酰胺组强。结论:中药肺积1号可通过提高机体免疫力以抗肿瘤。
Objective: To observe the effect of Pianji No.1 on lymphocyte subsets in mice with lung cancer and to explore the anti-tumor mechanism of Pianji No.1. Methods: The mouse model of lung cancer was established. The mice were randomly divided into healthy control group, tumor-bearing control group, traditional Chinese medicine group and cyclophosphamide group. After 14 days of administration, tumor index, tumor inhibition rate, thymus index, spleen index And T cell subsets change, splenic lymphocytes were isolated to observe the inhibition of Lewis lung cancer cell growth. Results: The Chinese medicine group and cyclophosphamide group were significantly inhibited tumor growth, Chinese medicine T cell subsets were corrected, compared with the healthy control group, the difference was not statistically significant (P> 0.05); cyclophosphamide group and tumor-bearing control group Immune imbalance existed in both groups. The ability of anti-tumor cells in spleen lymphocytes of traditional Chinese medicine group was stronger than that of tumor-bearing control group and cyclophosphamide group. Conclusion: Traditional Chinese medicine Pianji No.1 can improve tumor immunity by increasing immunity.