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观察放置３种不同类型宫内节育器（ＩＵＤ）妇女置器前、后子宫内膜超微结构及官腔冲洗液前列腺素（ＰＧｓ）含量、组织型纤溶酶原激活剂（ｔ－ＰＡ）和纤溶酶原激活剂抑制剂（ＰＡＩ）活性以及凝血因子Ⅷ相关抗原（ｖＷＦ）含量的动态变化。结果：①ＦＩＣｕ－ＩＵＤ对子宫内膜损伤较ＦＣｕ－ＩＵＤ及ＴＣｕ１２２０Ｃ明显减轻。②置入ＦＣｕ－ＩＵＤ和ＴＣｕ２２０Ｃ后１、３、６个月，６－ｋｅｔｏ－ＰＧＦ_（１ａ）／ＴＸＢ_２比值显著高于置器前（Ｐ＜０．０１或Ｐ＜０．０５），ＰＧＥ_２／ＰＧＦ_２比值升高不明显；置器后ｔ－ＰＡ活性升高显著（Ｐ＜０．０１），ＰＡＩ活性则无明显变化；ｖＷＦ含量置器前、后无统计学差异。③放置ＦＩＣｕ－ＩＵＤ前后，以上各项生化指标的差异均无统计学意义，但与同期 ＦＣｕ－ＩＵＤ和 ＴＣｕ２２０Ｃ相比，６－ｋｅｔｏ－ＰＧＦ_（１ａ）／ＴＸＢ_２比值及 ｔ－ＰＡ活性下降有显著性意义。提示：ＦＩＣｕ－ＩＵＤ释放的吲哚美辛通过减轻Ｃｕ－ＩＵＤ引起的内膜损伤和异物反应，降低Ｃｕ－ＩＵＤ所致的ＰＧＩ２、ｔ－ＰＡ升高和提高ＴＸＡ_２水平，是其减少子宫出血的部分机制。
The levels of prostaglandin (PGs), tissue plasminogen activator (t-PA) and tissue plasminogen activator (t-PA) in uterine endometrium of uterine endometrium before and after the placement of three kinds of IUDs Plasminogen activator inhibitor (PAI) activity and the dynamic changes of coagulation factor Ⅷ related antigen (vWF). Results: ①FICu-IUD significantly reduced endometrial damage compared with FCu-IUD and TCu1220C. ② The ratio of 6-keto-PGF_ (1a) / TXB_2 was significantly higher than that before preincubation (P <0.01 or P <0.05) at 1,3,6 months after implantation of FCu-IUD and TCu220C, PGE_2 / (P <0.01). PAI activity did not change significantly. There was no significant difference in vWF content between before and after treatment. ③ Before and after placement of FICu-IUD, there was no significant difference in the above biochemical indexes, but the ratio of 6-keto-PGF_ (1a) / TXB_2 and t-PA activity decreased significantly compared with FCu-IUD and TCu220C Sexual meaning. Hints: Indometacin released by FICu-IUD can reduce the increase of PGI2, t-PA and TXA_2 induced by Cu-IUD by reducing the intimal damage and foreign body reaction induced by Cu-IUD, which can reduce uterine bleeding Part of the mechanism.