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观察放置3种不同类型宫内节育器(IUD)妇女置器前、后子宫内膜超微结构及官腔冲洗液前列腺素(PGs)含量、组织型纤溶酶原激活剂(t-PA)和纤溶酶原激活剂抑制剂(PAI)活性以及凝血因子Ⅷ相关抗原(vWF)含量的动态变化。结果:①FICu-IUD对子宫内膜损伤较FCu-IUD及TCu1220C明显减轻。②置入FCu-IUD和TCu220C后1、3、6个月,6-keto-PGF_(1a)/TXB_2比值显著高于置器前(P<0.01或P<0.05),PGE_2/PGF_2比值升高不明显;置器后t-PA活性升高显著(P<0.01),PAI活性则无明显变化;vWF含量置器前、后无统计学差异。③放置FICu-IUD前后,以上各项生化指标的差异均无统计学意义,但与同期 FCu-IUD和 TCu220C相比,6-keto-PGF_(1a)/TXB_2比值及 t-PA活性下降有显著性意义。提示:FICu-IUD释放的吲哚美辛通过减轻Cu-IUD引起的内膜损伤和异物反应,降低Cu-IUD所致的PGI2、t-PA升高和提高TXA_2水平,是其减少子宫出血的部分机制。
The levels of prostaglandin (PGs), tissue plasminogen activator (t-PA) and tissue plasminogen activator (t-PA) in uterine endometrium of uterine endometrium before and after the placement of three kinds of IUDs Plasminogen activator inhibitor (PAI) activity and the dynamic changes of coagulation factor Ⅷ related antigen (vWF). Results: ①FICu-IUD significantly reduced endometrial damage compared with FCu-IUD and TCu1220C. ② The ratio of 6-keto-PGF_ (1a) / TXB_2 was significantly higher than that before preincubation (P <0.01 or P <0.05) at 1,3,6 months after implantation of FCu-IUD and TCu220C, PGE_2 / (P <0.01). PAI activity did not change significantly. There was no significant difference in vWF content between before and after treatment. ③ Before and after placement of FICu-IUD, there was no significant difference in the above biochemical indexes, but the ratio of 6-keto-PGF_ (1a) / TXB_2 and t-PA activity decreased significantly compared with FCu-IUD and TCu220C Sexual meaning. Hints: Indometacin released by FICu-IUD can reduce the increase of PGI2, t-PA and TXA_2 induced by Cu-IUD by reducing the intimal damage and foreign body reaction induced by Cu-IUD, which can reduce uterine bleeding Part of the mechanism.