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目的观察中成药康妇炎胶囊治疗宫颈高危型HPV(HR-HPV)感染的临床疗效,并初步探讨其作用机理。方法选取2013年1月-2014年1月在该院门诊就诊的宫颈HR-HPV感染患者60例,随机分为治疗组和对照组,每组各30例。治疗组采用中成药康妇炎胶囊药粉宫颈上药,对照组采用安达芬(重组人干扰素α-2b栓)阴道上药,比较两组治疗前后HRHPV病毒负荷量值、临床症状、宫颈的表面情况等。结果治疗组治疗总有效率、宫颈柱状上皮异位改善情况均高于对照组,差异均有统计学意义(P均<0.05);但两组HPV转阴率比较,差异无统计学意义(P>0.05)。治疗后,两组HPV-DNA病毒载量均明显下降,各组内治疗前后比较,差异有统计学意义(P<0.05);两组间比较,差异无统计学意义(P>0.05)。治疗前后两组血常规、尿常规、肝肾功能、心电图均为正常值。结论康妇炎胶囊能明显改善患者的临床症状,减轻宫颈局部炎症反应,并能有效降低宫颈HR-HPV感染的病毒载量,提高HR-HPV转阴率。
Objective To observe the clinical efficacy of Zhongcheng medicine Kangfuyan capsule in the treatment of cervical high-risk HPV (HR-HPV) infection, and to explore its mechanism of action. Methods Sixty patients with cervical HR-HPV infection who were diagnosed in the clinic from January 2013 to January 2014 were randomly divided into treatment group and control group, with 30 cases in each group. The treatment group was treated with proprietary Chinese medicine Kangfuyan Capsule powder on the cervix, and the control group was treated with Andafen (recombinant interferon α-2b suppository) on the vagina. The HRHPV viral load values, clinical symptoms, and cervix surfaces before and after treatment were compared between the two groups. Situation and so on. Results The total effective rate of treatment and the improvement of cervical columnar epithelium in the treatment group were higher than those in the control group (P<0.05). However, there was no significant difference in the negative rate of HPV between the two groups (P>0.05). >0.05). After treatment, both HPV-DNA viral load decreased significantly in both groups. There was a significant difference between the two groups before and after treatment (P<0.05). There was no significant difference between the two groups (P>0.05). Before and after treatment, blood, urine, liver and kidney function, and electrocardiogram were normal in the two groups. Conclusion Kangfuyan capsule can obviously improve the clinical symptoms of patients, reduce the local inflammatory reaction of cervical cervix, and can effectively reduce the viral load of cervical HR-HPV infection and increase the negative rate of HR-HPV.