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目的探讨宫腔镜下多发性子宫内膜息肉切除术后应用孕激素预防息肉复发的临床疗效。方法将2012年1月至2013年7月在内蒙古医科大学附属医院行宫腔镜诊治的94例多发性子宫内膜息肉患者分为观察组和对照组各47例,观察组术后予以安宫黄体酮周期性治疗3个月,对照组术后予以随访观察。比较两组患者术后6、12、24个月息肉复发、血红蛋白水平、子宫内膜厚度以及妊娠情况。结果观察组术后子宫内膜息肉的复发率为4.3%,明显低于对照组的17.4%,差异有统计学意义(P<0.05);观察组患者术后6、12、24个月的血红蛋白水平均明显高于对照组,而术后6、12、24个月的子宫内膜厚度均低于对照组,差异均有统计学意义(P<0.05),两组之间的妊娠率的差异无统计学意义(P>0.05)。结论宫腔镜联合孕激素治疗多发性子宫内膜息肉能有效的防止息肉的复发,同时亦能改善其术后血红蛋白水平,降低子宫内膜厚度,改善患者生活质量。
Objective To investigate the clinical efficacy of progestin in preventing recurrence of polyp after hysteroscopic multiple endometrial polypectomy. Methods From January 2012 to July 2013, 94 cases of multiple endometrial polyps treated by hysteroscopy in the Affiliated Hospital of Inner Mongolia Medical University were divided into observation group and control group, 47 cases in each group. Cyclone treatment for 3 months, the control group were followed up. The recurrence of polyps, hemoglobin, endometrial thickness and pregnancy were compared between the two groups at 6, 12, and 24 months after operation. Results The recurrence rate of endometrial polyps in observation group was 4.3%, which was significantly lower than that in control group (17.4%, P <0.05). The hemoglobin of 6,12,24 months (P <0.05). The difference of pregnancy rate between the two groups was significant No statistical significance (P> 0.05). Conclusion Hysteroscopy combined with progesterone in the treatment of multiple endometrial polyps can effectively prevent the recurrence of polyps, but also improve the postoperative hemoglobin level, reduce the thickness of endometrium and improve the quality of life of patients.