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目的 探讨胎粪吸入综合征 (MAS)与儿童哮喘的相关性。方法 调查 1986年 1月至 2 0 0 0年 1月曾住湖北省妇保院新生儿科的新生儿MAS患儿儿童时期哮喘的发病情况及其相关围生期、遗传、环境因素 ,并与对照组进行比较 ,分析MAS与儿童哮喘的相关性。结果 (1)MAS患儿儿童期哮喘的发生率为 2 1 2 % ,显著高于对照组的 4 0 % (P <0 0 0 1)及国内普查数据 0 11%～ 2 0 3% ;(2 )MAS轻重程度与哮喘发病无关 (P >0 0 5 )。 (3)男性、有难产史者MAS患儿哮喘发病显著高于对照组 (均P <0 0 5 ) ;(4)遗传因素两组差异无显著性意义 ;(5 )环境因素 :父、母低文化水平、家庭低经济收入两组差异有显著性意义 (分别 P <0 0 5 ,P <0 0 0 1,P <0 0 5 )。结论 MAS与儿童哮喘明显相关 ;相关因素有男性、有难产史者、父母低文化水平、家庭低经济收入 ,而MAS轻重程度与哮喘发病无关
Objective To investigate the correlation between meconium aspiration syndrome (MAS) and childhood asthma. Methods The incidence of asthma and its related perinatal, genetic and environmental factors in newborn infants with childhood asthma who lived in neonatal maternity and adulthood from January 1986 to January 2000 in Hubei Province were investigated and compared with the control Groups were compared to analyze the association of MAS with childhood asthma. Results (1) The incidence of childhood asthma in children with MAS was 21.2%, significantly higher than 40% (P <0.01 01) in the control group and 0 11% -230% in the domestic census data. ( 2) The severity of MAS was not related to the incidence of asthma (P> 0.05). (3) In male, the incidence of asthma in children with MAS was significantly higher than that in the control group (all P <0.05); (4) There was no significant difference between the two groups in genetic factors; (5) Environmental factors: There was significant difference between the two groups (P <0 05, P 0 01, P 0 05, respectively). Conclusions MAS is significantly associated with childhood asthma; the factors associated with males are those with history of dystocia, low levels of parental education, and low family income, whereas the severity of MAS is not associated with asthma