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目的检测原发性双侧乳腺癌左右两侧病理石蜡切片中CEA和PTEN表达和表达强度差异,揭示其发生是单克隆还是独立克隆性。对比分析双侧病灶之间以及与单侧同病理类型之间蛋白表达差异。方法 9例原发性双侧乳腺癌左右组织标本共18个,对应单侧乳腺癌患者乳腺组织标本10个。免疫组织化学法检测CEA和PTEN表达情况。结果双侧乳腺癌第一癌与第二癌和单侧乳腺癌中CEA表达率分别为66.6%,55.5%,60%、PTEN在第一癌、第二癌、单侧乳腺癌中表达率分别为33.3%,44.4%,50%、表达差异均无统计学意义(P>0.05),双侧乳腺癌CEA中同为阳性为5例,同为阴性为3例,PTEN中同为阳性为3例,同为阴性为5例。结论双侧乳腺癌首发癌和单侧乳腺癌中CEA、PTEN蛋白的表达均无统计学差异。双侧乳腺癌第一癌与第二癌中CEA、PTEN蛋白的表达差异无统计学差异,提示双侧乳腺癌第一癌和第二癌为单克隆性。
Objective To detect the expression of CEA and PTEN in paraffin sections of left and right sides of primary bilateral breast cancer, and to reveal the difference between CEA and PTEN expression and their clonality. The differences of protein expression between bilateral lesions and unilateral pathological types were compared and analyzed. Methods Nine cases of primary bilateral breast cancer tissue samples of a total of 18, corresponding to breast cancer patients unilateral breast tissue samples 10. Immunohistochemistry was used to detect the expression of CEA and PTEN. Results The rates of CEA expression in primary breast cancer, secondary breast cancer and unilateral breast cancer were 66.6%, 55.5% and 60% respectively. The expression rates of PTEN in primary cancer, secondary cancer and unilateral breast cancer were 33.3%, 44.4%, 50%, respectively. There was no significant difference in expression between the two groups (P> 0.05). There were 5 positive cases in CEA of bilateral breast cancer, 3 negative cases and 3 positive cases in PTEN Cases, with the same negative in 5 cases. Conclusions The expression of CEA and PTEN protein in primary breast cancer and unilateral breast cancer both have no statistical difference. There was no significant difference in the expression of CEA and PTEN protein between the first and second cancers of bilateral breast cancer, suggesting that the first and second cancers of the bilateral breast cancer are monoclonal.