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目的初步探讨眼附属器淋巴增生性病变的发病情况、临床特征以及组织病理学特点和分型。方法收集112例经组织病理学诊断为眼附属器淋巴增生性病变患者的116份石蜡切片标本,分析归纳临床相关资料,进一步分析组织病理学特点,并根据2001年世界卫生组织淋巴及血液组织肿瘤分类方案进行重新分类诊断。结果患者年龄8～80岁,平均49岁。病程20d至22年,平均22个月。双眼患病者16例(14.3%)。临床常见表现为眼球突出、局限性肿块(69例,占61.6%)。组织病理学检查显示反应性淋巴细胞增生11例(9.8%),非典型淋巴细胞增生10例(8.9%),淋巴瘤91例(81.3%)。其中,黏膜相关组织型边缘带B细胞淋巴瘤74例(占淋巴瘤患者81.3%)。结论眼附属器淋巴增生性病变以黏膜相关组织边缘带B细胞淋巴瘤最为多见,好发于中老年人,临床表现为慢性迁延性病程,双眼发病并不少见。
Objective To investigate the incidence, clinical features, histopathological characteristics and classification of ocular adnexal lymphoepithelial lesions. Methods One hundred and sixty-one paraffin-embedded specimens of patients with pathologically diagnosed ocular adnexal lymphoproliferative lesions were collected. Clinical data were analyzed and summarized. Histopathological features were further analyzed. According to the 2001 World Health Organization lymphoid and hematological malignancies Classification scheme for reclassification diagnosis. Results Patients aged 8 to 80 years, mean 49 years. Course of 20d to 22 years, an average of 22 months. 16 cases of both eyes (14.3%). Common clinical manifestations of prominent eye, the limitations of mass (69 cases, accounting for 61.6%). Histopathological examination showed reactive lymphocyte hyperplasia in 11 cases (9.8%), atypical lymphoid hyperplasia in 10 cases (8.9%) and lymphoma in 91 cases (81.3%). Among them, 74 mucosal tissue-associated B-cell lymphoma (81.3% of lymphoma patients). Conclusions The ocular adnexal lymphoproliferative lesions are most common in B-cell lymphoma associated with mucosa-associated tissue margin and occur in the middle-aged and elderly patients. The clinical manifestation is chronic persistent disease course, and it is not uncommon for both eyes to develop the disease.