论文部分内容阅读
目的探讨黔南地区布依族和苗族女性三阴乳腺癌患者临床特征和预后影响因素,为黔南地区女性乳腺癌的防治提供参考研究。方法 2005年1月-2010年6月在黔南布依族苗族自治州人民医院诊断为三阴乳腺癌的女性患者88例。按民族将其分为布依族组43例,苗族组45例,分别比较两民族临床特征和预后影响因素。结果苗族组年龄、乳腺癌家族史、肿瘤大小、组织学分级和淋巴结转移与布依族组比较,差异有统计学意义(P<0.01);苗族组复发病例、转移病例、复发时间与布依族组比较,差异有统计学意义(P<0.05)。苗族组5年无病生存率和总生存率分别与布依族组比较,差异有统计学意义(P<0.05);单因素分析结果显示乳腺癌家族史、手术方式、淋巴结转移、肿瘤大小、组织学分期、化疗周期对5年生存状况有统计学意义(P<0.05)。淋巴结转移、肿瘤大小、组织学分级、化疗周期对5年生存率的影响有统计学意义(P<0.05)。结论苗族和布依族三阴乳腺癌患者临床特征和预后影响因素有差异。临床诊疗中应高度重视。
Objective To investigate the clinical characteristics and prognostic factors of Buyi and Miao female triple negative breast cancer patients in Qiannan area and to provide reference for the prevention and treatment of female breast cancer in southern Guizhou. Methods From January 2005 to June 2010, 88 female patients with triple negative breast cancer were diagnosed in People ’s Hospital of Qiannan Buyi and Miao Autonomous Prefecture. According to ethnic groups, they were divided into Buyi group (43 cases) and Miao group (45 cases). The clinical characteristics and prognostic factors of the two ethnic groups were compared respectively. Results The Miao group’s age, family history of breast cancer, tumor size, histological grade and lymph node metastasis were significantly different from Buyi group (P <0.01); Miao group’s recurrence, metastasis, recurrence time and Buyi group The difference was statistically significant (P <0.05). The 5-year disease-free survival rate and overall survival rate in Miao group were significantly different from that in Buyi group (P <0.05). The results of univariate analysis showed that family history of breast cancer, operation method, lymph node metastasis, tumor size, School staging, chemotherapy cycle of 5-year survival was statistically significant (P <0.05). Lymph node metastasis, tumor size, histological grade and chemotherapy cycle had a significant effect on 5-year survival rate (P <0.05). Conclusion There are differences in the clinical characteristics and prognosis of Mian and Buyi trigeminal breast cancer patients. Clinical diagnosis and treatment should attach great importance.