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山东省中草药避孕研究协作组通过对棉籽抗生育有效成份的动物筛选,确定棉酚为抗生育作用的有效成份,为进一步探索其抗生育作用环节及有效剂量,进行了棉酚、醋酸棉酚对大鼠的抗生育作用的实验。结果:棉酚30毫克/公斤/日、醋酸棉酚30毫克/公斤/日,给药40天,在交配试验中即有明显的抗生育效果,怀孕率皆为零,但对动物的性生活无明显影响。副睾精子活力及形态在高剂量组给药41天时已有显著改变,精子活力降低,且有较多的
The Shandong Province Chinese Herbal Contraceptive Research Collaborating Group determined the gossypol as an effective ingredient for anti-fertility effects through animal screening of anti-fertility effective components of cottonseeds. To further explore its anti-fertility action links and effective doses, gossypol and gossypol acetate were used. Experiments on the anti-fertility effects of rats. RESULTS: Gossypol 30 mg/kg/day, gossypol acetate 30 mg/kg/day, administration for 40 days, there was a significant anti-fertility effect in the mating test, the pregnancy rate was zero, but the sexual life of the animals No significant effect. The vitality and morphology of the sperm of the epididymis significantly changed at the 41-day administration in the high-dose group, and sperm motility decreased, and there was more