论文部分内容阅读
A copper-catalyzed aerobic oxidative ring expansion reaction of isatins with 1,2,3,4-tetrahydroisoquinoline for the synthesis of tetra-cyclic quinazolinones has been developed.This reaction is performed smoothly under simple conditions to give the corresponding products in moderate to good yields with good functional group tolerance.The capacity of the resultant 5H-isoquinolino[1,2-b]quina-zolin-8(6H)-one for a range of palladium-catalyzed directing C-H activation has been further demonstrated,thus giving a broader access to diverse tetracyclic quinazolinones.