寻找克服乏氧细胞放射抗拒性的有效方法已成为近年来放射治疗发展的一个方向。1963年ADA-MS 氏提出电子亲和力与增敏作用有关的理论。1972年CHAMPMAN 氏报告灭滴灵(FLAGYL)有增敏作用。由于灭滴灵毒性低,体内半存留期较长,动物实验中显示有明显增敏作用等特点,U-RTASON 氏于1973年首先把它应用于临床。在大脑胶质母细胞瘤的放射治疗中证明灭滴灵确有增敏 Finding an effective way to overcome the radioresistance of hypoxic cells has become a trend in the development of radiation therapy in recent years. In 1963, ADA-MS proposed the theory of electron affinity and sensitization. In 1972 CHAMPMAN reported that chloramphenicol (FLAGYL) had sensitizing effect. Due to the low toxicity of metronidazole, longer half-life in vivo, and obvious sensitizing effects in animal experiments, U-RTASON first applied it in clinical practice in 1973. It has been demonstrated that metronidazole does sensitize in radiotherapy of brain glioblastoma