Langley 于1878年首先提出“受体学说”,试图在分子水平上解释药物作用的理论,这一理论已被当代的大量实验和临床实践所证实。Ahlquist 于1948年提出α、β肾上腺素能受体概念,进一步推动了有关α、β受体兴奋与拮抗药物的研究。其后,Szentivanyi 提出哮喘是由于β受体功能低下或阻断,内稳机制不能 Langley first proposed the “receptor theory” in 1878 in an effort to explain the theory of drug action at the molecular level. This theory has been confirmed by the large number of contemporary experiments and clinical practice. Ahlquist in 1948 put forward the concept of α, β adrenergic receptors, to further promote the α, β receptor excitability and antagonistic drugs. Later, Szentivanyi proposed asthma is due to poor or blocked beta receptor, the mechanism of instability can not