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目的:比较4种抗菌药物用于治疗外科感染性疾病患者的临床疗效。方法:选取2016年1月—2017年1月间医院收治的普外科外科感染性疾病患者150例,根据感染类型的不同将其随机分为4组,即大肠杆菌感染患者37例分为治疗Ⅰ组(20例)和治疗Ⅱ组(17例),以及葡萄球菌感染患者30例分为治疗Ⅲ组(15例)和治疗Ⅳ组(15例);治疗Ⅰ组患者给予硫酸阿米卡星注射液治疗,治疗Ⅱ组患者给予阿莫西林胶囊治疗,治疗Ⅲ组患者给予注射用苯唑西林钠治疗,治疗Ⅳ组患者给予注射用盐酸万古霉素治疗,比较4组患者用药后的痊愈率、感染发生率以及治疗过程中不良反应的发生率。结果:治疗Ⅰ组患者用药后痊愈率明显高于治疗Ⅱ组(P<0.05),治疗Ⅲ组患者用药后痊愈率明显高于治疗Ⅳ组(P<0.05);治疗过程中,治疗Ⅰ组患者不良反应的发生率明显低于治疗Ⅱ组(P<0.05),治疗Ⅲ组患者不良反应的发生率明显低于治疗Ⅳ组(P<0.05)。结论:合理使用抗菌药物对有效地防治外科感染具有重要意义,且能减少不良反应的发生率。
Objective: To compare the clinical efficacy of four antimicrobial agents in the treatment of patients with surgical infectious diseases. Methods: A total of 150 surgical cases of general surgical infection were selected from January 2016 to January 2017 in our hospital. According to the different types of infection, they were randomly divided into 4 groups. 37 patients with Escherichia coli infection were divided into treatment Ⅰ (N = 20) and treatment group (n = 17), and 30 patients with staphylococcal infection were divided into treatment group (15 cases) and treatment group (n = 15). Patients in treatment group Ⅰ were given amikacin sulfate injection Liquid treatment, the treatment group Ⅱ patients given amoxicillin capsule treatment, the treatment group Ⅲ patients given injection of oxacillin sodium treatment, the treatment group Ⅳ patients given injection of vancomycin hydrochloride treatment, the cure rate of the four groups were compared after treatment, The incidence of infection and the incidence of adverse reactions during treatment. Results: After treatment, the cure rate of patients in group Ⅰ was significantly higher than that in group Ⅱ (P <0.05). The cure rate of patients in group Ⅲ after treatment was significantly higher than that in group Ⅳ (P <0.05). During the treatment, patients in group Ⅰ The incidence of adverse reactions was significantly lower than that of treatment group Ⅱ (P <0.05). The incidence of adverse reactions in treatment group Ⅲ was significantly lower than that of treatment group Ⅳ (P <0.05). Conclusion: The rational use of antimicrobial agents is of great importance for the prevention and treatment of surgical infections, and can reduce the incidence of adverse reactions.