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目的探讨血清肿瘤标志物癌胚抗原(CEA)、糖类抗原199(CA199)、神经元特异性烯醇(NSE)、细胞角蛋白21-1片段(CYFRA21-1)检测对肺癌诊断的临床价值。方法检测肺癌组97例、肺良性病组64例及健康体检组41例患者血清CEA、CA199、NSE、CYFRA21-1含量。结果肺癌患者的四种肿瘤标志物血清水平及其阳性率均明显高于肺良性病组及健康体检组(P<0.01);CEA在肺腺癌中阳性率最高(66.7%),CYFRA21-1在肺鳞癌中阳性率最高(69.2%),NSE在肺小细胞癌中阳性率最高(76.9%),CA199在非小细胞性肺癌中阳性率较高(腺癌42.2%、鳞癌43.6%)。四者联合检测对肺癌的诊断敏感性为89.7%、准确性为85.1%。结论联合检测上述四项肿瘤标志物在肺癌诊断中具有较高的临床价值。
Objective To investigate the clinical value of serum tumor markers CEA, CA199, NSE and CYFRA21-1 in the diagnosis of lung cancer . Methods Serum levels of CEA, CA199, NSE and CYFRA21-1 were detected in 97 lung cancer patients, 64 benign pulmonary disease patients and 41 healthy volunteers. Results The serum levels and positive rates of four tumor markers in patients with lung cancer were significantly higher than those in benign lung and healthy subjects (P <0.01). The positive rates of CEA in lung adenocarcinoma were the highest (66.7%), CYFRA21-1 The positive rate was the highest in lung squamous cell carcinoma (69.2%), NSE was the highest in small cell lung cancer (76.9%), CA199 was higher in non-small cell lung cancer (42.2% in adenocarcinoma, 43.6% ). The four combined detection of lung cancer diagnostic sensitivity was 89.7%, the accuracy of 85.1%. Conclusion The combined detection of the above four tumor markers in the diagnosis of lung cancer has a high clinical value.