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本文以CCl_4等因素所致大鼠肝损伤、肝纤维化为模型,以血清ALT活性、Alb含量、肝Hyp含量、肝组织HE和胶原染色光镜观察等为观察内容,分预防和治疗实验观察大黄廑虫丸的防治作用,并设西药秋水仙碱组对照。结果表明:大黄廑虫丸有较显著的抗慢性肝损伤作用及一定的抗肝纤维化作用。在抗肝损伤,保护肝功能方面,较秋水仙碱为优;但在抗肝纤维化方面,尚不及秋水仙碱作用强。
In this paper, liver damage and hepatic fibrosis induced by CCl_4 and other factors were used as models, and serum ALT activity, Alb content, liver Hyp content, liver tissue and collagen staining were observed under light microscopy, and were divided into experimental and preventive observations. The prevention and treatment of rhubarb locust pills and the western medicine colchicine group control. The results showed that: Dahuangqichong Pill has more significant anti-chronic liver injury and a certain anti-hepatic fibrosis. In the aspect of anti-hepatic injury and protection of liver function, colchicine is superior; but in the aspect of anti-hepatic fibrosis, it is not as strong as colchicine.