本文报告1例表现为鼻衄的血小板功能障碍。患者44岁女性,为行右侧Manchester氏Ⅱ期乳癌整形术而接受癌化疗。在每月的每一周期内按下列剂量计划用药:5-氟脲嘧啶静注500mg/天,连用5天;环磷酰胺静注500mg/天,连用5天;氨甲喋呤口服5mg/天,连用5天。每间歇28天周期性给这些药达9个月。在停止化疗后两周,患者有多次严重鼻衄,次日有新的鼻衄而输新鲜血,鼻填塞并同时给以其它支持疗法。鼻衄虽获控制,但在第三天发现全身遍布紫癜。因常规血液学检查无骨髓抑制证据而作了有关血 This article reports 1 case of platelet dysfunction manifested as epistaxis. The 44-year-old woman underwent cancer chemotherapy for his second breast cancer surgery on the right. In each of the monthly cycle of drug use the following dose planning: 5 - fluorouracil intravenous 500mg / day, once every 5 days; cyclophosphamide 500mg / day intravenously, once every 5 days; methotrexate oral 5mg / day, with 5 day. The drugs are given periodically for 28 months at intervals of 9 months. Two weeks after cessation of chemotherapy, the patient had multiple severe epistaxis, new epistaxis the next day and new blood, nasal packing and other supportive therapies. Although control of epistaxis, but found in the third day of purpura throughout the body. Relevant blood was made from evidence of myelosuppression without routine hematology