论文部分内容阅读
目的:观察硫化氢对帕金森病(Parkinson’s disease,PD)大鼠神经行为学、氧化应激以及多巴胺及其代谢产物的影响。方法:采用6-羟基多巴胺(6-OHDA)注射于脑右侧黑质造成偏侧PD模型。将模型动物随机分为模型组、硫化氢组(硫氢化钠做供体),每组10只;另分别取10只正常大鼠为正常组及假手术组(以抗坏血酸注射)。观察PD大鼠经过硫化氢处理后神经行为学、脑组织丙二醛(MDA)、谷胱甘肽(GSH)、超氧化物歧化酶(SOD)含量以及多巴胺代谢产物的变化。结果:与模型组比较硫化氢组大鼠行为学明显改善(P<0.01),同时脑组织中GSH、SOD含量均升高,MDA含量降低,多巴胺及其代谢产物升高。结论:硫化氢对PD模型大鼠多巴胺神经元具有保护作用。
Objective: To observe the effects of hydrogen sulfide on neurobehavioral, oxidative stress and dopamine and its metabolites in Parkinson’s disease (PD) rats. Methods: 6-hydroxydopamine (6-OHDA) injected into the right substantia nigra of the brain resulted in a hemiparkinsonian PD model. The model animals were randomly divided into model group, hydrogen sulfide group (sodium hydrosulfide donor), each group of 10; the other 10 normal rats were normal group and sham operation group (ascorbic acid injection). The neurobehavioral changes, malondialdehyde (MDA), glutathione (GSH) and superoxide dismutase (SOD) contents and the changes of dopamine metabolites in PD rats after H2S treatment were observed. Results: Compared with the model group, the behavior of H2S group was significantly improved (P <0.01). At the same time, the content of GSH and SOD in brain tissue increased, MDA content decreased and dopamine and its metabolites increased. Conclusion: Hydrogen sulfide has a protective effect on dopamine neurons in PD model rats.