目前,肠出血性大肠杆菌(EHEC)被公认为一种重要的人类肠道致病菌。该菌所致疾病以出血性肠炎和溶血性尿毒综合征最为重要。约10%感染EHEC发生腹泻,并发展成肠外后遗症的儿童中,以溶血性尿毒综合征最多见。溶血性尿毒综合征患者中将近30%发生严重并发症,如长期的肾脏或脑损害。在该菌致病物质中,志贺样毒素(SLTs)被认为与发展成出血性肠炎和全身性并发症有关。鉴于牛是EHEC的自然宿 At present, enterohemorrhagic Escherichia coli (EHEC) is recognized as an important human intestinal pathogenic bacteria. The disease caused by the bacteria to hemorrhagic enteritis and hemolytic uremic syndrome is the most important. About 10% of children infected with EHEC who develop diarrhea and develop parenteral sequelae are the most commonly seen hemolytic uremic syndrome. Nearly 30% of patients with hemolytic uremic syndrome have serious complications such as long-term kidney or brain damage. Shiga-like toxins (SLTs) are thought to be associated with the development of hemorrhagic enteritis and systemic complications in the pathogens of this bacterium. Given that cattle are natural places for EHECs