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目的探讨左甲状腺素钠片治疗妊娠并甲状腺功能减退对母婴的影响。方法选取医院2013年1月-2014年11月收治的妊娠并甲状腺功能减退患者206例,将其随机分为试验组和对照组各103例,试验组患者接受左甲状腺素钠片治疗,对照组采用常规治疗,比较两种治疗方案对母婴预后的影响。结果试验组孕妇妊娠期高血压发病率低于对照组,经阴道分娩率高于对照组,极低体质量婴儿比例低于对照组,新生儿并发症的发病率及新生儿畸形的发生率均低于对照组,差异均有统计学意义(P<0.05)。2组患者产后出血率差异无统计学意义(P>0.05)。结论左甲状腺素钠片治疗妊娠并甲状腺功能减退具有良好的治疗效果,对母婴预后促进生长发育、降低并发症等具有良好的作用,值得在临床中应用与推广。
Objective To investigate the effect of levothyroxine sodium tablets on pregnancy and hypothyroidism in mothers and infants. Methods Totally 206 pregnant women with hypothyroidism admitted from January 2013 to November 2014 in our hospital were randomly divided into experimental group and control group (n = 103). The patients in trial group were treated with levothyroxine sodium tablets and the control group Routine treatment was used to compare the effects of the two treatment regimens on maternal and infant outcomes. Results The incidence of gestational hypertension in pregnant women in the experimental group was lower than that in the control group. The vaginal delivery rate was higher in the experimental group than in the control group. The proportion of very low birth weight infants was lower than that of the control group. The incidence of neonatal complications and neonatal malformation Lower than the control group, the difference was statistically significant (P <0.05). There was no significant difference in postpartum hemorrhage between the two groups (P> 0.05). Conclusions Levothyroxine sodium tablets have a good therapeutic effect in the treatment of pregnancy with hypothyroidism and have a good effect on the prognosis of maternal and infant to promote the growth and reduce complications. It is worthy of clinical application and promotion.