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重症急性胰腺炎(severe acute pancreatitis,SAP)来势凶猛,病程进展快,死亡率高达20%-30%[1]。肠道是应激反应的中心器官之一,大量研究显示SAP容易发生肠屏障功能障碍(intestine barrier functional disturbance,IBFD),IBFD是SAP并发感染、甚至形成腹腔脓肿,诱发和加重全身炎症反应综合征(SIRS)、多器官功能障碍综合症(MODS),且死亡率居高不下的关键所在[2,3]。现就SAP时IBFD发生机制的研究进展做一综述。
Severe acute pancreatitis (SAP) is fierce and has a fast course of progression with a mortality rate of 20% -30% [1]. Intestinal tract is one of the central organs of stress response, a large number of studies have shown that SAP is prone to intestinal barrier dysfunction (IBFD), IBFD is SAP complicated infection, and even the formation of abdominal abscess, induced and aggravated systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), and the key to high mortality [2,3]. Now on SAP when the mechanism of IBFD research progress is reviewed.