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目的观察CHOP方案用于非何杰金氏恶性淋巴瘤临床治疗的效果及毒副作用。方法 82例非何杰金氏恶性淋巴瘤患者以CHOP方案施治,其中,初次治疗者42例为初治组,重复治疗者40例为复治组,比较两组疗效及毒副作用。结果初治组完全缓解(CR)、部分缓解(PR)、总有效率(RR)均与复治组比较,差异无统计学意义(P>0.05)。初治组的白细胞下降、血小板减少、脱发、指趾麻木皆显著低于复治组,差异有统计学意义(P<0.05)。结论采用CHOP方案治疗非何杰金氏恶性淋巴瘤患者,可使初次治疗、重复治疗者得到相似的疗效,但复治者的部分毒副作用比初治者严重,需得到重视。
Objective To observe the effect and side effects of CHOP regimen in the treatment of non-Hodgkin’s lymphoma. Methods Eighty - two non - Hodgkin ’s lymphoma patients were treated with CHOP regimen. Among them, 42 cases of initial treatment were treated with initial treatment and 40 cases with repeated treatment were treated with CHOP. The curative effect and side effect were compared between the two groups. Results The complete remission (CR), partial remission (PR) and total effective rate (RR) in the initial treatment group were significantly different from those in the retreatment group (P> 0.05). The initial treatment group leukopenia, thrombocytopenia, hair loss, toe numbness were significantly lower than the retreatment group, the difference was statistically significant (P <0.05). Conclusions The CHOP regimen is effective in the treatment of non-Hodgkin’s lymphoma patients with initial treatment and repeated treatment. However, some of the toxic and side effects of retreatment are more serious than those of the primary treatment and need attention.