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目的:观察镇静催眠药物和抗抑郁药物联合使用对口腔癌患者术后睡眠紊乱的治疗效果。方法:选择口腔癌患者33例作为研究对象,随机分为对照组(n=16)和试验组(n=17),对照组给予口腔癌患者术后一般常规治疗和护理,试验组术后第3天给予盐酸曲唑酮片50mg+阿普唑仑片0.4mg鼻饲,分别观察两组患者的睡眠改善情况。结果:在匹兹堡睡眠质量指数(PSQI)总分比较上,试验组睡眠好于对照组,差异有统计学意义,P<0.05。在PSQI成分指数的比较上,试验组在睡眠质量、入睡时间和睡眠时间上均好于对照组,差异有统计学意义,P<0.05。结论:阿普唑仑和盐酸曲唑酮联合使用可以较好的改善口腔癌患者术后的睡眠紊乱。
Objective: To observe the therapeutic effect of combination of sedative and hypnotic drugs and antidepressants on postoperative sleep disturbance in patients with oral cancer. Methods: Totally 33 oral cancer patients were randomly divided into control group (n = 16) and experimental group (n = 17). Patients in control group were given routine treatment and nursing after operation. The patients in control group 3 days given trazodone hydrochloride tablets 50mg + alprazolam tablets 0.4mg nasal feeding, were observed in two groups of patients with sleep improvement. Results: In the Pittsburgh Sleep Quality Index (PSQI) score comparison, the experimental group sleep better than the control group, the difference was statistically significant, P <0.05. Compared with PSQI, the experimental group had better sleep quality, sleep time and sleep time than the control group, the difference was statistically significant (P <0.05). Conclusion: The combination of alprazolam and trazodone hydrochloride can improve the postoperative sleep disturbance in oral cancer patients.