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目的 研究携氧液对大鼠高血压脑出血脑组织的保护作用。方法 通过立体定向手术对大鼠脑尾状核用胶原酶加肝素联合注射诱导大鼠出血模型 ,观察各组大鼠脑含水量、组织形态学、脑血流及生化指标的变化。结果 B组 (非携氧液组 )患侧组织形态学及细胞器损伤明显较 A组 (携氧液组 )严重 ;B组脑含水量 (80 .5 5± 0 .80 % )高于 A组 (77.94± 1.16 % )、B组髓鞘碱性蛋白 (MBP)和神经元特异性烯醇化酶 (NSE)分别为 0 .87± 0 .44 ng/ml、1.74± 0 .6 8ng/ml,A组为 0 .5 4± 0 .19ng/ml、1.19± 0 .49ng/m l,两组具有显著性差异 (均 P <0 .0 1)。结论 携氧液对高血压脑出血的血肿周围脑组织有良好的保护作用
Objective To study the protective effect of oxygen carrying solution on brain tissue of hypertensive intracerebral hemorrhage in rats. Methods The rat model of hemorrhage was induced by collagenase and heparin injection through stereotactic surgery. The changes of brain water content, histomorphology, cerebral blood flow and biochemical indexes were observed. Results The histopathology and organelle damage in group B (non-oxygenated fluid group) were significantly more severe than those in group A (group B). Brain water content in group B (80.55 ± 0.80%) was higher than that in group A (77.94 ± 1.16%), MBP and NSE in group B were 0.87 ± 0.44 ng / ml and 1.74 ± 0.68 ng / ml respectively, There was significant difference between the two groups (all P <0.01) in group A, which was 0.54 ± 0.19ng / ml and 1.19 ± 0.49ng / ml respectively. Conclusion Oxygen-carrying fluid has a good protective effect on brain tissue around hematoma of hypertensive intracerebral hemorrhage