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目的 探讨大剂量甲基强的松龙 (MP)对局灶性缺血再灌注大鼠脑保护作用的机理。方法 采用大鼠局灶性脑缺血再灌注模型 ,观察缺血前后应用大剂量 MP对大鼠大脑中动脉闭塞侧梗死体积的影响以及脑含水量的变化 ,同时观察脑组织病理学改变。结果 缺血前后 MP治疗组大脑中动脉供血区脑梗死体积较盐水对照组明显减小 (均 P<0 .0 1) ;缺血前后 MP治疗组与盐水对照组脑含水量比较无明显差别 (均 P>0 .0 5 )。病理学发现盐水对照组脑组织血管周围可见巨噬细胞浸润 ,而 MP治疗组无此病理改变。结论 大剂量 MP可改善缺血性脑损伤 ,其机理与减小缺血区梗死体积、抑制脑组织巨噬细胞浸润有关
Objective To investigate the mechanism of brain protective effect of high-dose methylprednisolone (MP) on focal ischemia-reperfusion in rats. Methods The model of focal cerebral ischemia-reperfusion in rats was used to observe the effect of high-dose MP on cerebral infarction volume and cerebral water content in middle cerebral artery occlusion rats. The pathological changes of brain were also observed. Results The volume of cerebral infarction in MP-treated group was significantly lower than that in saline-treated group (all P <0.01). There was no significant difference in brain water content between MP-treated group and saline control group before and after ischemia All P> 0. 05). Pathological findings showed that macrophages infiltrated around the blood vessels of the saline control group, while no pathological changes were observed in the MP treated group. Conclusion High-dose MP can improve ischemic brain injury, the mechanism of which is related to reducing infarct size and inhibiting macrophage infiltration in cerebral tissue