论文部分内容阅读
目的比较十二指肠溃疡患者晨服奥美拉唑,睡前加服法莫替丁和加服奥美拉唑后日间酸突破(DAB)和夜间酸突破(NAB)的情况。方法将20例十二指肠溃疡患者随机分成两组,日间服用奥美拉唑20mg后,一组睡前加服奥美拉唑20mg,一组睡前加服法莫替丁40mg,疗程1周。治疗前后行夜间胃酸pH监测。结果治疗后奥美拉唑组夜间pH<4的中位时间百分比减少62.4%,法莫替丁组减少83.95%,两组之间比较P<0.05。奥美拉唑组NAB发生率为70%,法莫替丁组NAB发生率为30%,两组之间比较P<0.001。两组日间pH<4的中位时间百分比、DAB的发生率差异无显著性(P>0.05)。结论睡前服用法莫替丁比睡前服用奥美拉唑对夜间胃酸分泌和酸突破的控制更为有效。
Objective To compare omeprazole with morning service in patients with duodenal ulcer, plus daytime acid breakthrough (DAB) and nocturnal acid breakthrough (NAB) after bedtime plus famotidine plus omeprazole. Methods Twenty patients with duodenal ulcer were randomly divided into two groups. After taking omeprazole 20mg during the day, one group was given 20mg omeprazole before bedtime. One group was given famotidine 40mg before going to bed, 1 week. Nighttime gastric acid pH monitoring was performed before and after treatment. Results The omeprazole group had a 62.4% decrease in the median time to pH <4 at night, a decrease of 83.95% in the famotidine group, and a P <0.05 between the two groups. The incidence of NAB was 70% in omeprazole group and 30% in famotidine group, P <0.001. There was no significant difference in the percentage of median time between pH <4 and the incidence of DAB between the two groups (P> 0.05). Conclusions Taking famotidine at bedtime is more effective than nocturnal administration of omeprazole on nocturnal gastric acid secretion and acid breakthrough.