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目的 研究胆固醇酯转运蛋白 (CETP)与各种类型的血脂异常和血糖异常的关系。方法 1999年 9月至 10月 ,在北京市自然人群中采用分层随机抽样方法进行危险因素的横断面调查。分析了 719名 4 5～ 6 4岁的男女两性的血浆CETP浓度与血脂、血糖的关系。结果 (1)在正常甘油三酯 (TG)组 ,CETP低于第 2 5百分位数与高于第 75百分位数时低高密并脂蛋白胆固醇 (HDL C)的患病率分别为 7 4 %和 5 3%。在高TG组 ,CETP低于第 2 5百分位数时低HDL C的患病率也仅为3 6 % ,与正常TG组相似 ;但CETP大于第 75百分位数时低HDL C的患病率为 35 7% ,是CETP低于第 2 5百分位数组的 10倍 ,且高低密度脂蛋白胆固醇 (LDL C)和高极低密度脂蛋白胆固醇 (VLDL C)的患病率也最高。 (2 )高TG合并低HDL C组 ,CETP高于第 75百分位数者占 5 0 0 % ,明显高于其他各组(P <0 0 5 )。 (3)采用Logistic回归模型调整了年龄、性别、吸烟、饮酒、肥胖、血糖和总胆固醇后 ,CETP大于第 75百分位数组与小于第 2 5百分位数组相比患高TG低HDL C型血脂异常的危险显著增加 ,OR =10 94 ,P =0 0 2 5。 (4 )高TG和 (或 )低HDL C者合并高血糖的患病率亦较高 (P <0 0 0 1) ,但仅在CETP较高者中 ,高血糖患病率增加有显著性 (P <0 0 0 1)。结论 CETP
Objective To investigate the relationship between cholesteryl ester transfer protein (CETP) and various types of dyslipidemia and abnormal blood glucose. Methods From September to October 1999, a stratified random sampling method was used to investigate the cross-sectional investigation of risk factors among the natural population in Beijing. The relationship between plasma CETP concentrations and blood lipids and blood glucose in 719 men and women aged from 4 to 6 years old was analyzed. Results (1) The prevalence of low density lipoprotein cholesterol (HDL C) in normal triglycerides (TG) group with CETP lower than the 2 5th percentile and higher than 75th percentile were 7 4% and 53%. In the high-TG group, the prevalence of low-HDL C was only 36% when the CETP was lower than the 25th percentile, similar to the normal TG group; however, the CETP was lower than the 75th percentile The prevalence was 35.7%, a 10-fold lower CETP than the 25th percentile and the prevalence of high and low-density lipoprotein cholesterol (LDL C) and high-density low-density lipoprotein cholesterol (VLDL C) Also the highest. (2) Those with high TG combined with low HDL C had higher CETP than the 75th percentile, which was significantly higher than other groups (P <0.05). (3) After adjusted for age, sex, smoking, alcohol consumption, obesity, blood glucose and total cholesterol by Logistic regression model, patients with CETP larger than 75th percentile had higher TG, lower HDL C than those with less than 25th percentile The risk of dyslipidemia was significantly increased, OR = 10 94, P = 0 0 2 5. (4) The prevalence of hyperglycemia in patients with high TG and / or low HDL C was also higher (P <0.01), but only in those with higher CETP, the prevalence of hyperglycemia was significantly higher (P <0 0 0 1). Conclusion CETP