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[目的]分析伽玛刀立体定向放射治疗原发性肝癌的疗效及预后因素。[方法]对66例原发性肝癌患者行伽玛刀治疗,以50%~70%的等剂量曲线覆盖95%的计划靶区,处方剂量3.8~6.0Gy/次,照射次数6~10次,肿瘤剂量30~60Gy,照射3次/周,隔日1次,总疗程2~3周。[结果]近期疗效总有效率(CR+PR)为80.3%(53/66),1、2、3年生存率分别为48.5%、24.2%、18.2%。Cox多因素分析显示肿瘤分期和肿瘤最大径是独立预后影响因素。[结论 ]伽玛刀治疗能有效改善原发性肝癌的肿瘤局部控制率和预后。
[Objective] To analyze the curative effect and prognostic factors of Gamma knife radiotherapy for primary liver cancer. [Method] 66 patients with primary liver cancer were treated with Gamma Knife. 95% of the planned target area was covered by isodose curve of 50% -70%. The prescription dose was 3.8-6.0 Gy per dose and the number of irradiation was 6-10. , Tumor dose 30 ~ 60Gy, irradiation 3 times / week, every other day, the total course of treatment of 2 to 3 weeks. [Results] The total effective rate (CR + PR) of the immediate effect was 80.3% (53/66). The 1, 2, 3-year survival rates were 48.5%, 24.2% and 18.2% respectively. Cox multivariate analysis showed that tumor stage and tumor diameter were the independent prognostic factors. [Conclusion] Gamma knife treatment can effectively improve the local control rate and prognosis of primary liver cancer.