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目的:探讨经鼻蝶窦入路显微手术及溴隐亭药物治疗育龄期妇女垂体泌乳素微腺瘤的临床治疗效果。方法:研究2007年4月-2010年11月收治的65例育龄期女性垂体泌乳素微腺瘤患者,经鼻蝶显微手术40例,药物(溴隐亭)保守治疗25例,对手术治疗和药物治疗后患者月经恢复情况、血PRL变化及生育情况进行统计学分析。结果:手术治疗和药物治疗后月经恢复情况、血PRL变化差异无统计学意义(P>0.05);手术治疗和药物治疗后生育情况差异有统计学意义(P<0.05),手术组优于药物治疗组。结论:在育龄期女性垂体泌乳素微腺瘤的治疗上,经鼻蝶显微手术治疗优于药物(溴隐亭)保守治疗,但在实际治疗方案选择上应根据患者具体情况进行个性化治疗。
Objective: To investigate the clinical effect of transnasal sphenoid sinus approach microsurgery and bromocriptine drug treatment of pituitary prolactinomas in women of childbearing age. Methods: From April 2007 to November 2010, 65 cases of pituitary prolactinomas in women of childbearing age were studied. Forty patients underwent microsurgical nasal microsurgery and conservative treatment with drug (bromocriptine). 25 patients underwent surgical treatment And after treatment of patients with menstruation recovery, blood PRL changes and fertility were statistically analyzed. Results: There was no significant difference in the changes of PRL between surgical treatment and post-treatment menstruation (P> 0.05). There was a significant difference in fertility between surgical treatment and drug treatment (P <0.05) therapy group. Conclusions: In the treatment of pituitary prolactinomas in women of childbearing age, microsurgical treatment of transnasal papillae is superior to conservative treatment of drug (bromocriptine). However, the actual treatment options should be personalized according to the patient’s specific conditions .