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目的探讨不同CD4~+T和CD8~+T淋巴细胞基线值HIV/AIDS患者接受高效抗逆转录病毒治疗(HAART)后免疫重建的效果。方法流式细胞术检测100名HIV/AIDS患者治疗前及采用不同CD4~+T和CD8~+T淋巴细胞基线值接受HAART后的CD4~+T和CD8~+T淋巴细胞水平,对其做统计学分析。结果当HIV/AIDS患者治疗前CD4~+T细胞数(个/μL)分别为≤50、>50-200、>200-350及>350-500时,接受HAART后分别升高98.55、73.1、111和102.2(P<0.05或<0.01);仅治疗前CD8~+T细胞基线水平(个/μL)≤500时HAART后升高39.8(P<0.01)。结论治疗前基线CD4~+T或CD8~+T水平影响HAART后免疫重建的效果;定期监测CD4~+T和CD8~+T变化,有助于了解HIV/AIDS患者的病情发展和选择正确的治疗方案。
Objective To investigate the effect of immunosurveillance on HIV / AIDS patients with different baseline CD4 + T and CD8 + T lymphocytes after receiving high effective antiretroviral therapy (HAART). Methods Flow cytometry was used to detect the levels of CD4 + T and CD8 + T lymphocytes in 100 HIV / AIDS patients before and after treatment with different CD4 + T and CD8 + T lymphocytes Statistical analysis. Results When the number of CD4 ~ + T cells (a / μL) were ≤50,> 50-200,> 200-350 and> 350-500 respectively before treatment, the levels of CD4 ~ + T cells increased by 98.55 and 73.1, 111 and 102.2, respectively (P <0.05 or <0.01). The baseline levels of CD8 + T cells (a / μL) ≤ 500 before HAART increased 39.8 (P <0.01) after HAART. Conclusions The baseline CD4 + T or CD8 + T level before treatment affects the immune reconstitution effect after HAART. Regular monitoring of the changes of CD4 + T and CD8 + T contributes to the understanding of the progression of HIV / AIDS and the correct choice Treatment programs.