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目的观察早期经鼻空肠管肠内营养支持在重症急性胰腺炎(SAP)患者治疗中的应用效果。方法将54例SAP患者随机分成对照组和试验组各27例,所有患者均予抗感染、抑制胰液分泌、抑酸、补液等常规治疗,试验组于发病后72h放置鼻空肠管并给予肠内营养(EN),比较2组患者平均住院日、住院费用、腹痛缓解时间、血淀粉酶恢复时间、并发症发生率,检测2组治疗前、治疗2周后白蛋白(ALB)、前白蛋白(PA)、谷草转氨酶(AST)、乳酸脱氢酶(LDH)水平。结果对照组1例患者因多脏器功能衰竭死亡,试验组患者治疗后顺利出院,与对照组相比,试验组患者在平均住院日、住院费用、腹痛缓解时间、血淀粉酶恢复时间、并发症发生率均明显优于对照组,差异有统计学意义,治疗2周后检测试验组患者白蛋白、前白蛋白水平均高于对照组,差异有统计学意义(P<0.05),2组患者治疗后AST、LDH水平均降至正常,差异无统计学意义(P>0.05);结论在SAP患者中早期实行肠内营养是简单有效的,在促进患者康复过程中发挥重要作用。
Objective To observe the effect of early nasogastrointestinal enteral nutrition support in the treatment of patients with severe acute pancreatitis (SAP). Methods 54 cases of SAP were randomly divided into control group and experimental group of 27 cases, all patients were anti-infective, inhibition of pancreatic juice secretion, acid suppression, rehydration and other routine treatment, the experimental group placed nasal jejunal tube at 72h after onset and given enteral Nutrition, EN, average length of hospital stay, hospitalization expenses, abdominal pain relief time, blood amylase recovery time and complication rate were compared between the two groups before treatment and two weeks after treatment. The levels of albumin (ALB), prealbumin (PA), aspartate aminotransferase (AST), lactate dehydrogenase (LDH) levels. Results One patient in the control group died of multiple organ failure, and the patients in the experimental group were discharged smoothly after treatment. Compared with the control group, the patients in the experimental group had significant differences in mean length of stay, hospitalization cost, abdominal pain relief time, blood amylase recovery time, The incidence of disease was significantly higher than that of the control group, the difference was statistically significant. After 2 weeks of treatment, the levels of albumin and prealbumin in the test group were significantly higher than those in the control group (P <0.05) The levels of AST and LDH in patients after treatment were all reduced to normal, with no significant difference (P> 0.05). Conclusion Early enteral nutrition in SAP patients is simple and effective and plays an important role in promoting the rehabilitation of patients.