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阿托品与东莨菪碱均自茄科植物颠茄与曼陀罗等提得。北京制药工业研究所于1973年开始对东莨菪碱的工业合成法进行了研究并获成功。尔后,在此基础上对东莨菪碱进行结构改造,合成了溴化异丙基东莨菪碱(8-Isopropylscopolamine)。本所药理室对溴化异丙基东莨菪碱、氢溴酸东莨菪碱、溴化异丙基阿托品(Ipratro-
Atropine and scopolamine are derived from Solanaceae Belladonna and Mandala. Beijing Institute of Pharmaceutical Industry in 1973 began scopolamine industrial synthesis was studied and successful. Then, on this basis scopolamine structural transformation, synthesis of isopropyl bromide scopolamine (8-Isopropylscopolamine). Pharmacology laboratories of this Division of isopropyl bromide scopolamine, scopolamine hydrobromide, isopropyl atropine bromide (Ipratro-