苯妥英钠是常用的抗癲痫药和抗心律失常药之一。近十几年来国外发表了大量有关它的临床药理和药物动力学研究的资料,为临床设计合理治疗方案,提高疗效和减少毒副反应提供了理论基础。由于苯妥英钠的药效和毒性与血药浓度密切相关以及癲痫病人对药物反应具有明显的个体差异性,因而对长期用药患者进行血药浓度监测,以确保用药的疗效和安 Phenytoin sodium is one of the commonly used antiepileptic and antiarrhythmic drugs. In the last ten years, a great deal of information about its clinical pharmacology and pharmacokinetics has been published in foreign countries, which provides a theoretical basis for clinical design of rational treatment plan, improvement of curative effect and reduction of side effects. Because of the pharmacodynamics and toxicity of phenytoin and blood concentration is closely related to the epilepsy patients with significant individual differences in response to drugs, thus long-term drug use in patients with plasma concentration monitoring to ensure the efficacy and safety of medication